The crash occurred on the D’Aguilar Highway at Stony Creek, north-west of Brisbane this morning.
Queensland Police confirmed the cars hit each other head on, and that the scene was extremely confronting for emergency personnel.
It’s believed the crash was due to a mechanical fault with one of the vehicles, and investigations are still underway.
The impact of the collision forced a white ute off the road, where it was found mangled in a ditch.
A 52-year-old man was pronounced dead at the scene.
Two women suffered critical injuries and were saved by passing paramedics.
They were airlifted to hospital.
A child, another man and a 13-year old boy were also hospitalised with less severe injuries.
Zoe Henrichs, an acting supervisor of operations with Queensland Ambulance Service, said five patients in total were treated for their injuries.
“We had a huge response with critical care paramedics, high acuity paramedics and multiple advanced care paramedics,” she said.
“This was a big response from all services, we all worked really well together.”
She added due to wet conditions it was difficult for paramedics to access their patients.
“We had to slow down as we drove through the conditions, particularly with the wet weather.”
Surrounding roads were closed for hours as the Forensic Crash Unit investigated the accident.
One dead, two fighting for life after horror crash north of Brisbane